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What is PROCESS VALIDATION? What does PROCESS VALIDATION mean? PROCESS VALIDATION meaning
 
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BROWSE The Internet EASY way with The Audiopedia owned Lightina Browser Android app! INSTALL NOW - https://play.google.com/store/apps/details?id=com.LightinaBrowser_8083351 What is PROCESS VALIDATION? What does PROCESS VALIDATION mean? PROCESS VALIDATION meaning - PROCESS VALIDATION definition - PROCESS VALIDATION explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/by-sa/3.0/ license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6UuCPh7GrXznZi0Hz2YQnQ Process Validation is the analysis of data gathered throughout the design and manufacturing of a product in order to confirm that the process can reliably output products of a determined standard. Regulatory authorities like EMA and FDA have published guidelines relating to process validation. The purpose of process validation is to ensure varied inputs lead to consistent and high quality outputs. Process validation is an ongoing process that must be frequently adapted as manufacturing feedback is gathered. End-to-end validation of production processes is essential in determining product quality because quality cannot always be determined by finished-product inspection. Process validation can be broken down into 3 steps: process design, process qualification, and continued process verification. Design of experiments is used to discover possible relationships and sources of variation as quickly as possible. A cost benefit analysis should be conducted to determine if such an operation is necessary. Quality by Design is an approach to pharmaceutical manufacturing that stresses quality should be built into products rather than tested into products; that product quality should be considered at the earliest possible stage rather than at the end of the manufacturing process. Input variables are isolated in order to identify the root cause of potential quality issues and the manufacturing process is adapted accordingly. Process Analytical Technology is used to measure critical process parameters (CPP) and critical quality attributes (CQA). PAT facilitates measurement of quantitative production variables in real time and allows access to relevant manufacturing feedback. PAT can also be used in the design process to generate a process qualification. Critical Process Parameters Operating parameters that are considered essential to maintaining product output within specified quality target guidelines. Critical Quality Attributes (CQA) are chemical, physical, biological and microbiological attributes that can be defined, measured, and continually monitored to ensure final product outputs remain within acceptable quality limits. CQA are an essential aspect of a manufacturing control strategy and should be identified in stage 1 of Process Validation: Process design. During this stage acceptable limits, baselines, and data collection and measurement protocols should be established. Data from the design process and data collected during production should be kept by the manufacturer and used to evaluated product quality and process control. Historical data can also help manufacturers better understand operational process and input variables as well as better identify true deviations from quality standards compared to false positives. Should a serious product quality issue arise, historical data would be essential in identifying the sources of errors and implementing corrective measures. Design Space Verification confirms that quality can be guaranteed within an identified range of input and operating variables. Continued Process Verification is the ongoing monitoring of all aspects of the production cycle. It aims to ensure that all levels of production are controlled and regulated. Deviations from prescribed output methods and final product irregularities are flagged by a process analytics database system. The FDA requires production data be recorded (FDA requirements (§ 211.180(e)). Continued process verification is stage 3 of process validation. The European Medicines Agency defines a similar process known as Ongoing Process Verification. This alternative method of process validation is recommended by the EMA for validating processes on a continuous basis. Continuous Process Verification analyses Critical Process Parameters and Critical Quality Attributes in real time to confirm production remain within acceptable levels and meet standards set by ICH Q8, Pharmaceutical Quality Systems, and Good manufacturing practice.
Views: 10063 The Audiopedia
October 2018 ACIP Meeting - Adult & Child/Adolescent Immunization schedule
 
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Proposed 2019 adult immunization schedule;Proposed 2019 child and adolescent immunization schedule; Public comment; Immunization schedules recommendations vote Comments on this video are allowed in accordance with our comment policy: http://www.cdc.gov/SocialMedia/Tools/CommentPolicy.html This video can also be viewed at https://www.cdc.gov/vaccines/videos/low-res/ACIPOct2018/ImmunScheld_LowRes.mp4
Understanding storage conditions with temperature range
 
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This video explains various types of storage conditions for pharmaceutical products along with temperature range. The pharmaceutical products need to be stored at these temperature conditions depending upon the manufacturer instruction or provided in monograph.
Views: 882 Professor Tushar
Acetone
 
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This page refers to the chemical compound. For the slowcore band, see Acetone (band). Acetone (systematically named propanone) is the organic compound with the formula (CH3)2CO. It is a colorless, volatile, flammable liquid, and is the simplest ketone. This video is targeted to blind users. Attribution: Article text available under CC-BY-SA Creative Commons image source in video
Views: 847 Audiopedia
शारंगधर मसलटोन के फायदे Sharangdhar Muscle Tone Multipurpose Tonic in Hindi & review
 
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शारंगधर मसलटोन के फायदे Sharangdhar Muscle Tone Multipurpose Tonic in Hindi & review This is a multipurpose tonic that strengthens muscles, nerves and bones. Elements like shatavari, ashwagandha, arjun, aamalki, vidarikand and mandur in Muscle tone are immensely helpful as they provide the requisite nutrition. An increase in blood count indicates improvement in resistance power. This tonic is extremely useful for children in their growing years as it boosts muscle growth make the bones stronger & improves physique. Muscle tone also maintains bone mass in those the age of above 50 years . It increases resistance power, thus preventing frequent bouts of illness. excellent natural tonic for sportsman. The tonic is useful for all. Indications:Loss of muscular strength and its motivating action in any age group, Rickets, Weight loss, General debility, Paralytic conditions also supportive in sexual debility. Compositions:Each tablet contains:Shatavari (Asparagus racemosus), 40 mgAshwagandha (Withania somnifera), 40 mgArjun (Terminalia arjuna), 40 mgAmalaki (Emblica officinalis) 40mgVidari Kand (Ipomoea digitata), 120mgMandoor Bhasma, 10mgBinders and Excipients q.s. Benefit:Muscle tone is a multipurpose tonic which nourishes the muscles.Bones and neurons as well as increases their strength and general body weight.It also increases calcium and increases strength of bones and muscles.He contents of muscle tone increase the blood forming minerals and hence increase blood supply to bones and muscles. Do’s : Milk , milk products , sweets , nutritional food like almond, coconut and water , fruits , green vegetables, black currents , tomato , dates. Daily regime: Yogasane , Walking , Suryanamaskar. Don’t: Malnourished food, stale food, spicy food , alcohol , smoking , over exertion , sleeping late at night. Dose :2 tablets 2 to 3 times with milk or water after both meals. #onlinemedicine,#medicine,#ayurveda,#ayurved ,#Ayurvedic
Views: 6690 Medicine Reviews
Norflox TZ Tablet - Uses  and Side Effects
 
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Read more - https://justdoc.com/medicine/norflox-tz-tablet-for-bacterial-infection Norflox TZ is an antibiotic used to treat bacterial infections in stomach, intestines, urinary tract, skin, throat, genitals, lungs, nose and other body parts as well as to treat some sexually transmitted diseases. Norflox Tablet is made from : Norfloxacin (400 mg) - It is used to treat bacterial infections in urinary tract, ear-nose-throat, female genitalia, lungs, skin and brain. Tinidazole (600 mg) - It is an anti-parasitic anti-bacterial drug that is used to treat protozoan infections & some bacterial infections in stomach (intestinal tract), vagina, skin tissues and other body parts. Lactobacillus (120 million cells) - "Friendly" Bacteria that helps in treating diarrhea by breaking down the food, improving absorption of nutrients and bringing gastrointestinal tract back bacterial level to normalcy. Norflox TZ tablet should be taken in prescribed quantiy by the doctor or a nutritionist. It is advised to take this medicine with food or immediately after food. You can buy norflox from a local pharmacy & there are many generic variants available as well. The drug is considered inexpensive by popular opinion. It comes in strip with 10 tablets and you can use as per the requirement. Please check the expiry of package before buying. It is manufactured by Cipla Ltd. How to use Norflox TZ Tablet? It should be taken orally as per the prescribed dosage. Unless you are using chewable medicine, do not crush, break or chew a tablet and swallow it as a whole.
Views: 25035 Justdoc Accounts
GPAT 2019 - IMPORTNAT SUBJECTS FOR GPAT 2019
 
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#gpat #gpat2019 #bpharmacy Is video me gpat ke important subjects ke baare me bataya hai aur kon kon se subjects aapko padhne chahaiye iske baare me maine is video me bataya hai. Watch my another videos - 1) HOW TO BECOME DRUG INSPECTOR - https://youtu.be/exIqaEifQUE 2) ALL ABOUT CHEGG.COM - https://youtu.be/9YzfxewQ_rI 3) ALL ABOUT GPAT EXAM - https://youtu.be/SUp8nTyhOLU 4) B.PHARMACY OR PHARM.D WHICH IS BETTER ? - https://youtu.be/mDM8mDstfn8 5) ALL ABOUT NIPER EXAM - https://youtu.be/qRvr3PxzWtc 6) PHARMACY CAREER IN INDIA - https://youtu.be/X77A6irYdjE 7) CAREER SCOPE AFTER B.PHARM - https://youtu.be/ixgHD40C6Xo 8) HOW TO BECOME PILOT IN INDIA - https://youtu.be/_wYSosODtS0 9) CAREER IN PHARMACOVIGILLANCE - https://youtu.be/KdKshHXyD0Q 10) STUDY ABROAD FOR FREE - https://youtu.be/jJVxXF4Jx8c Connect me on - FACEBOOK - https://m.facebook.com/vishwable1/ INSTAGRAM - https://www.instagram.com/vishal_n_only_vishal_/ Hope you like this video. Thanks for watching 🙂 Keep watching and keep supporting vishal wable live :-)
Views: 62 vishal wable live
DRUG STABILITY EVALUATION METHODS
 
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Description of Various Methods being used to Evaluate Drugs and their Formulations
Views: 2972 Pharma Foundation
DRUG INSPECTOR, GPAD, NIPER, DHA, PROMETRIC AND MOH PHARMACY MCQS WITH ANSWER
 
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DRUG INSPECTOR, GPAD, NIPER, DHA, PROMETRIC AND MOH PHARMACY MCQS WITH ANSWER ( Dimethyl sulphoxide Is commonly used as an excipient In transdermal patches as?,Ideal conditions for effective transdermal drug delivery would Include molecular weight of ---------------and pH of------------------- for the saturated aqueous solution of the drug.,All of the following drugs are believed to undergo significant first-pass hepatic biotransformation, except? )
Views: 60 Siva Balan
Levantar el ánimo con remedios naturales, por Adolfo Pérez Agustí
 
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Levantar el ánimo con remedios naturales, por Adolfo Pérez Agustí, que tuvo lugar en Ecocentro (Madrid) el 3 de Agosto 2017. ADOLFO PÉREZ AGUSTÍ lleva 40 años dedicado a la medicina natural, ha publicado más de 300 libros que están a la venta en el portal Amazon e imparte conferencias gratuitas por toda España. Está diplomado en Naturopatía, Herbodietética, Nutrición y Preparación física, habiendo cursado estudios de Botánica medicinal y Genética en la Universidad Complutense de Madrid.. En la actualidad imparte docencia en la Cruz Roja Española y academias privadas. Su interés se centra en divulgar sus conocimientos para conseguir que los gobiernos del mundo entero apoyen a las medicinas alternativas sin reservas, y así beneficiar a los enfermos http://www.edicionesmasters.com ------------------------------EVENTO ORGANIZADO POR------------------------------ Ecocentro (Madrid) http://www.ecocentro.es ------------------------------------INFORMACION SOBRE MINDALIA------------------------------ Mindalia.com y Mindalia Televisión son una ONG SIN ANIMO DE LUCRO Si te ha gustado este video, APOYANOS CON UNA DONACION: https://www.paypal.com/cgi-bin/webscr?cmd=_s-xclick&hosted_button_id=G58CS4AVKC6BU SUSCRIBETE AL CANAL DE YOUTUBE para no perderte ningún video: http://www.youtube.com/subscription_center?add_user=mindaliacom AYUDA A MINDALIA, SIN PAGAR NI UN SÓLO CÉNTIMO MÁS, CON TUS COMPRAS Y RESERVAS ONLINE: http://helpfree.ly/j20544 MILES DE VIDEOS de conferencias y entrevistas de interés en http://www.mindaliatelevision.com Participa en las CONFERENCIAS EN DIRECTO: http://television.mindalia.com/category/conferencias-en-directo/ -Puedes escuchar este y otros audios en Ivoox: http://mindaliacomradio.ivoox.com PIDE O ENVIA AYUDA http://www.mindalia.com - La Red Social de Ayuda a través del Pensamiento SIGUENOS EN REDES SOCIALES: -Youtube: http://www.youtube.com/mindaliacom -Facebook: https://www.facebook.com/mindalia.ayuda/ -Twitter: http://twitter.com/mindaliacom -Pinterest: https://es.pinterest.com/mindaliacom/ DESCARGATE LAS APLICACIONES MOVILES GRATUITAS: Mindalia Multimedia https://play.google.com/store/apps/details?id=es.app.mindalia_television Mindalia Red de Ayuda https://play.google.com/store/apps/details?id=es.app.mindalia_ayuda&hl=es CONTACTA CON NOSOTROS: http://television.mindalia.com/contacto/ -Skype: mindalia.com ¿Tienes un video que te gustaría que publicáramos? Envíanoslo!! ----------------------------------------------------------------------------------- ***Mindalia Televisión no se hace responsable de las opiniones vertidas en este video, ni necesariamente participa de ellas. ***Mindalia Televisión no se responsabiliza de la fiabilidad de las ***informaciones de este video, cualquiera que sea su origen. Este video es exclusivamente informativo.
Views: 307965 Mindalia Televisión
NHLBI Small Biz Hangout: Biologics Regulation Overview
 
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The US FDA’s Center for Biologics Evaluation and Research (CBER) regulates products based upon therapeutic modality – blood products, vaccines, and cell/gene/tissue therapies. Given the diversity of these therapy types - what core information does FDA look for when deciding to allow investigational use of a new biologic? What are your responsibilities as a sponsor to maintain communication with FDA throughout your development work? Are there special programs you can take advantage of, or standard requirements you should know about? A hypothetical case study pulls together the various stages of biologics development to describe one potential product development pathway. Chapter 1: Introduction 00:00 Chapter 2: What is a Biologic? 03:24 Chapter 3: FDA Review of Biologics 04:26 Chapter 4: Biologics IND Requirements 07:20 Chapter 5: IND Maintenance 15:55 Chapter 6: Special Programs for Biologics 23:56 Chapter 7: Biologics License Applications 30:08 Chapter 8: Case Study 36:59 Chapter 9: Final Q & A 48:16 Chapter 10: Contact Information 50:54
Views: 2072 NHLBI
Webinar - Quantitative At-Line Portable Raman for Process Control
 
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Quantitative At-Line Portable Raman for Process Control:Development, Validation, and Implementation, with a Pharmaceutical Example In this webinar, viewers will get an inside look at how portable Raman is being developed for at-line quantitation of nonionic surfactants in pharmaceutical formulations at Eli Lilly. In this context, we will examine the advantages of Raman over traditional HPLC methods, such as shorter analysis times, minimal sample prep and ease of at-line implementation. Follow Us Online! Facebook: https://www.facebook.com/BwTek Google Plus: https://www.google.com/+Bwtek Linkedin: https://www.linkedin.com/company/b&w-tek-inc- Twitter: https://twitter.com/bwtek Web: http://www.bwtek.com
Views: 308 B&W Tek
NUEVO GOBIERNO, LA MISMA CANCIÓN, NEWS #53.
 
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Ya tenemos nuevo gobierno tras casi un año con un gobierno en funciones , volvemos a tener al Partido Popular ahí. Ahí para decirnos simplemente que no a las drogas. Ahí con su represión hacia los consumidores y hacia las asociaciones. El mes pasado os comentamos la intervención al cultivo de cáñamo de Josep Pàmies, agricultor y activista público de las plantas medicinales. Este mes le ha tocado la intervención policial a Bernat Pellisa, ex alcalde de Rasquera, otra persona que ha propuesto abiertamente el cultivo legal de cannabis. En Estados Unidos 9 estados votarán este mes en las presidenciales sobre la marihuana. En Chile el autocultivo ya es legal. Y en España con el Partido Popular, nos quedamos atrás en la ola de legalización que viene de américa. Algo que molesta un poco después de haber exportado nuestro modelo de clubs a otros países. En Verde Medicina viajamos a Castellón para conocer a Jaime, con VIH y a Lidón que padece Esclerosis múltiple. Ambos nos contarán sobre las mejoras en su calidad de vida gracias a los tratamientos con cannabis. Además en Informe Drogas nos daremos un paseo por la fira d’Alimentació i Salut de Balaguer. Y también nos pasaremos por Americannabis en México. Miguel Gimeno nos acercará a la extracción con butano. Y yo misma, en la Barraca de María, os hablaré de la somango y de la white widow. www.marihuanatelevision.tv
Views: 5327 Marihuana Televisión
Our Miss Brooks: Mash Notes to Harriet / New Girl in Town / Dinner Party / English Dept. / Problem
 
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Our Miss Brooks is an American situation comedy starring Eve Arden as a sardonic high school English teacher. It began as a radio show broadcast from 1948 to 1957. When the show was adapted to television (1952--56), it became one of the medium's earliest hits. In 1956, the sitcom was adapted for big screen in the film of the same name. Connie (Constance) Brooks (Eve Arden), an English teacher at fictional Madison High School. Osgood Conklin (Gale Gordon), blustery, gruff, crooked and unsympathetic Madison High principal, a near-constant pain to his faculty and students. (Conklin was played by Joseph Forte in the show's first episode; Gordon succeeded him for the rest of the series' run.) Occasionally Conklin would rig competitions at the school--such as that for prom queen--so that his daughter Harriet would win. Walter Denton (Richard Crenna, billed at the time as Dick Crenna), a Madison High student, well-intentioned and clumsy, with a nasally high, cracking voice, often driving Miss Brooks (his self-professed favorite teacher) to school in a broken-down jalopy. Miss Brooks' references to her own usually-in-the-shop car became one of the show's running gags. Philip Boynton (Jeff Chandler on radio, billed sometimes under his birth name Ira Grossel); Robert Rockwell on both radio and television), Madison High biology teacher, the shy and often clueless object of Miss Brooks' affections. Margaret Davis (Jane Morgan), Miss Brooks' absentminded landlady, whose two trademarks are a cat named Minerva, and a penchant for whipping up exotic and often inedible breakfasts. Harriet Conklin (Gloria McMillan), Madison High student and daughter of principal Conklin. A sometime love interest for Walter Denton, Harriet was honest and guileless with none of her father's malevolence and dishonesty. Stretch (Fabian) Snodgrass (Leonard Smith), dull-witted Madison High athletic star and Walter's best friend. Daisy Enright (Mary Jane Croft), Madison High English teacher, and a scheming professional and romantic rival to Miss Brooks. Jacques Monet (Gerald Mohr), a French teacher. Our Miss Brooks was a hit on radio from the outset; within eight months of its launch as a regular series, the show landed several honors, including four for Eve Arden, who won polls in four individual publications of the time. Arden had actually been the third choice to play the title role. Harry Ackerman, West Coast director of programming, wanted Shirley Booth for the part, but as he told historian Gerald Nachman many years later, he realized Booth was too focused on the underpaid downside of public school teaching at the time to have fun with the role. Lucille Ball was believed to have been the next choice, but she was already committed to My Favorite Husband and didn't audition. Chairman Bill Paley, who was friendly with Arden, persuaded her to audition for the part. With a slightly rewritten audition script--Osgood Conklin, for example, was originally written as a school board president but was now written as the incoming new Madison principal--Arden agreed to give the newly-revamped show a try. Produced by Larry Berns and written by director Al Lewis, Our Miss Brooks premiered on July 19, 1948. According to radio critic John Crosby, her lines were very "feline" in dialogue scenes with principal Conklin and would-be boyfriend Boynton, with sharp, witty comebacks. The interplay between the cast--blustery Conklin, nebbishy Denton, accommodating Harriet, absentminded Mrs. Davis, clueless Boynton, scheming Miss Enright--also received positive reviews. Arden won a radio listeners' poll by Radio Mirror magazine as the top ranking comedienne of 1948-49, receiving her award at the end of an Our Miss Brooks broadcast that March. "I'm certainly going to try in the coming months to merit the honor you've bestowed upon me, because I understand that if I win this two years in a row, I get to keep Mr. Boynton," she joked. But she was also a hit with the critics; a winter 1949 poll of newspaper and magazine radio editors taken by Motion Picture Daily named her the year's best radio comedienne. For its entire radio life, the show was sponsored by Colgate-Palmolive-Peet, promoting Palmolive soap, Lustre Creme shampoo and Toni hair care products. The radio series continued until 1957, a year after its television life ended. http://en.wikipedia.org/wiki/Our_Miss_Brooks
Views: 89619 Remember This
Hydrated lime manufacturing
 
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Views: 38 Cowper Mill